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1.
Chinese Journal of Pediatrics ; (12): 825-828, 2011.
Article in Chinese | WPRIM | ID: wpr-356366

ABSTRACT

<p><b>OBJECTIVE</b>To analyze and evaluate the efficacy and safety of tacrolimus and low-dose steroids in the treatment of steroid-resistant nephrotic syndrome in children.</p><p><b>METHOD</b>Twenty-one children with steroid-resistant nephrotic syndrome enrolled from October 2008 to July 2010 into this retrospective longitudinal study received oral tacrolimus treatment, 0.1 to 0.15 mg/kg per day and once every 12 hours, and prednisone 0.2 to 0.75 mg/kg per day simultaneously. During the treatment, the plasma concentration of tacrolimus, urine volume, urine, serum creatinine and liver function were regularly monitored.</p><p><b>RESULT</b>After 1 to 3 months treatment, 14 cases showed complete remission and 7 cases had partial remission. Sixteen patients received renal biopsy, of whom 6 revealed minimal change nephropathy with complete remission in 3 cases, 3 cases had partial remission;4 cases revealed focal segmental glomerulosclerosis with 2 complete remission and 2 partial remission; other 5 children with IgM nephropathy and 1 mesangial proliferative glomerulonephritis achieved complete remission. Within treatment period, 6 patients presented transient adverse reactions, without altering the principle treatment strategy, but only taking the symptomatic treatment. During follow-up, 1 case was lost to follow-up and the remaining 20 cases were followed up from 2 months to 21 months. In 4 patients the disease relapsed within 1st-year follow-up, while at 2nd-year follow-up, 4 cases had (6 times) recurrence.</p><p><b>CONCLUSION</b>Tacrolimus showed a reliable effect in children with steroid-resistant nephrotic syndrome. Less adverse reactions were seen, and most of them could be tolerated. Nevertheless, the patients had a higher relapse rate after 1 to 2 years treatment. Therefore, the long-term effects of tacrolimus for steroid-resistant nephrotic syndrome remains to be further evaluated.</p>


Subject(s)
Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Drug Resistance , Longitudinal Studies , Nephrotic Syndrome , Drug Therapy , Prednisone , Therapeutic Uses , Retrospective Studies , Tacrolimus , Therapeutic Uses , Treatment Outcome
2.
Journal of Zhejiang University. Medical sciences ; (6): 365-367, 2005.
Article in Chinese | WPRIM | ID: wpr-355204

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the clinical application of lung function analysis in diagnosis of children respiratory diseases.</p><p><b>METHODS</b>Respiratory function was evaluated with portable lung function detector in 6 261 children with respiratory diseases. FEV1, FVC and PEFR were measured in 268 children with cough variant asthma (CVA) and 147 children with asthma (AS), and the results were self-compared during follow-up.</p><p><b>RESULT</b>There were no significant differences in above parameters between children with cough variant asthma and those with asthma (P>0.05). Lung functions of asthma children were improved evidently by administration of glycocorticoid inhalator (P<0.001).</p><p><b>CONCLUSION</b>Lung function detection is essential for diagnosis of asthma and it can be used as a reliable index for therapeutic effect of asthma children.</p>


Subject(s)
Adolescent , Child , Female , Humans , Male , Asthma , Follow-Up Studies , Respiration , Respiratory Function Tests
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